reference i.e. cholera
Cholera is an infection of the small intestine caused by the bacterium Vibrio cholerae. The main symptoms are watery diarrhea and vomiting. This may result in dehydration and in severe cases grayish-bluish skin. Transmission occurs primarily by drinking water or eating food that has been contaminated by the feces (waste product) of an infected person, including one with no apparent symptoms. The severity of the diarrhea and vomiting can lead to rapid dehydration and electrolyte imbalance, and death in some cases. The primary treatment is oral rehydration therapy, typically with oral rehydration solution, to replace water and electrolytes. If this is not tolerated or does not provide improvement fast enough, intravenous fluids can also be used. Antibacterial drugs are beneficial in those with severe disease to shorten its duration and severity. The primary symptoms of cholera are profuse diarrhea and vomiting of clear fluid. These symptoms usually start suddenly, half a day to five days after ingestion of the bacteria. The diarrhea is frequently described as "rice water" in nature and may have a fishy odor. Cholera is typically transmitted to humans by either contaminated food or water. Most cholera cases in developed countries are a result of transmission by food, while in the developing world it is more often water. Food transmission occurs when people harvest seafood such as oysters in waters infested with sewage. Although cholera may be life-threatening, prevention of the disease is normally straightforward if proper sanitation practices are followed. Undeveloped countries, due to nearly universal advanced water treatment and sanitation practices, cholera is no longer a major health threat. There are several points along the cholera transmission path at which its spread may be halted: Sterilization, Sewage, Sources, and Water purification. A number of safe and effective oral vaccines for cholera are available. Dukoral, an orally administered, inactivated whole cell vaccine, has an overall efficacy of about 52% during the first year after being given and 62% in the second year, with minimal side effects. Doxycycline is typically used first line, although some strains of V. cholerae have shown resistance. Other antibiotics proven to be effective include cotrimoxazole, erythromycin, tetracycline, chloramphenicol, and furazolidone.




